Vascular endothelial growth factor/platelet ratio as a potential biomarker for preeclampsia: A study of angiogenic markers in Pakistani patients

Author:

Khidri Feriha Fatima12ORCID,Waryah Yar Muhammad13,Nigar Roohi4,Mughal Zaib-Un-Nisa5,Zai Jawaid Ahmed5,Rao Ali Raza16,Ujjan Ikram Din6,Waryah Ali Muhammad1

Affiliation:

1. Molecular Biology and Genetics Department, Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

2. Department of Biochemistry, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

3. Sindh Institute of Opthalmology and Visual Sciences, Hyderabad, Pakistan

4. Department of Gynecology and Obstetrics, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

5. Department of Physiology and Medical Laboratory Technology, University of Sindh, Jamshoro, Pakistan

6. Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

Abstract

Objectives To determine the levels of angiogenic biomarkers: vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (sVEGFR1 or sFlt-1), platelet count, and the VEGF/platelet ratio in preeclampsia. Methods Forty-four cases of preeclampsia and 44 controls were recruited. Results The serum VEGF, sVEGFR1, and VEGF/platelet ratio were significantly higher and platelet counts lower in preeclampsia in comparison to controls (VEGF: median = 178 vs. 97 pg/mL, p < 0.0001, sVEGFR1: 1634 vs. 627 pg/mL, p < 0.0001, VEGF/platelet ratio: 1.148 vs. 0.417, and platelet count: 178 × 103/µL vs. 232 × 103/µL, p = 0.0006). The VEGF and VEGF/platelet ratio showed better diagnostic accuracy for differentiating preeclampsia, with an area under the curve of 97.47% (95% CI: 0.95–1.00) and 89.46% (95% CI: 0.82–0.96), respectively. VEGFA: c.-2055A>C (rs699947) AA genotype exhibited higher serum VEGF levels associated with preeclampsia. Conclusion The higher levels of angiogenic biomarkers in preeclampsia, suggest a role in the pathogenesis and potential diagnosis.

Publisher

SAGE Publications

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