Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease

Author:

Bleyer Anthony J12ORCID,Kidd Kendrah O12,Williams Adrienne H3,Johnson Emily4,Robins Victoria1,Martin Lauren1,Taylor Abbigail1,Kim Alice1,Bowline Isai1,Connaughton Dervla M56,Langefeld Carl D4,Zivna Martina2,Kmoch Stanislav12

Affiliation:

1. Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA

2. Research Unit of Rare Diseases, Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic

3. DNA Data Solutions, LLC, St. Petersburg, FL, USA

4. Division of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA

5. Schulich School of Medicine and Dentistry, University of Western Ontario, ON, Canada

6. Division of Nephrology, Department of Medicine, London Health Sciences Centre, London, Ontario, Canada

Abstract

Introduction Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described. Methods A cross-sectional survey was sent to women from ADTKD families. Results Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls ( p  =  0.54) and >40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were <37 weeks versus 0 in controls ( p < 0.0001). Cesarean section occurred in 19% of pregnancies in affected women versus 38% of unaffected individuals ( p  =  0.06). Only 12% of babies required a neonatal intensive care unit stay. Conclusions ADTKD pregnancies had lower rates of hypertension during pregnancy versus other forms of chronic kidney disease, which may have contributed to good maternal and fetal outcomes.

Funder

Soli Deo Gloria

NIH-NIDDK

Charles University in Prague

Black-Brogan Foundation

National Center for Medical Genomics

Ministry of Health of the Czech Republic

CKD Biomarkers Consortium Pilot and Feasibility Studies Program

Slim Health Foundation

Ministry of Education of the Czech Republic

Publisher

SAGE Publications

Subject

Obstetrics and Gynecology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Course and outcome of pregnancy in women with Alport syndrome;Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics);2024-07-12

2. Obstetric Medicine, impact factors and publishing;Obstetric Medicine;2023-08-31

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