Rhabdomyoblastic Differentiation in Malignant Melanoma in Adults: Report of 2 Cases

Author:

Gharpuray-Pandit Deepa1,Coyne John2,Eyden Brian3,Banerjee S. Sankar1

Affiliation:

1. Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom

2. Wythenshawe Hospital, Manchester, United Kingdom

3. Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom,

Abstract

Two cases of malignant melanoma are reported in adults exhibiting rhabdomyoblastic differentiation to alert pathologists to this rare variant of malignant melanoma. One of the cases presented as a metastasis in a submandibular lymph node, and the other was a primary skin melanoma. There are only a few published reports on melanocytic tumors with rhabdomyoblastic differentiation, mainly occurring in giant congenital nevi. Both cases reported here were confirmed by immunohistochemistry. Both cases were also studied by electron microscopy, and one showed distinctive ultrastructural features of striated muscle.

Publisher

SAGE Publications

Subject

Pathology and Forensic Medicine,Surgery,Anatomy

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