Affiliation:
1. The Second Hospital of Jilin University, Changchun, Jilin, China
Abstract
The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that was initially diagnosed as an inflammatory myofibroblastic tumor in our hospital and as liposarcoma after consultation. This article analyzed the features of this entity by reviewing the literature. Only 15 cases have been reported, most of which were misdiagnosed as sarcoma, sarcomatoid carcinoma, or inflammatory myofibroblastic tumor. Most of the reported cases showed a myxoid stroma, with a variable number of inflammatory cells. The hallmark cells usually can be found by careful evaluation of the slides. Immunohistochemistry including CD30, EMA, and ALK are the most useful for diagnosis. Most are III or IV stage, and have a good prognosis after chemotherapy.
Funder
Youth Program of National Natural Science Foundation of China
Jilin Province Department of Finance Project
Science and Technology of Jilin Province, Jilin Province Key Laboratory
The Role and Molecular Mechanism of EMT in the Resistance of ROS1-positive Lung Cancer
Subject
Pathology and Forensic Medicine,Surgery,Anatomy
Cited by
1 articles.
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1. Spindle cell tumors of the mediastinum;Annals of Diagnostic Pathology;2022-10