Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis-Reference-Cited by-同舟云学术

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Published:2024-03-08 Issue:6 Volume:30 Page:707-713
ISSN:1352-4585
Container-title:Multiple Sclerosis Journal
language:en
Short-container-title:Mult Scler

Author:

Aprea Maria Grazia¹^ORCID,Schiavetti Irene²^ORCID,Portaccio Emilio¹^ORCID,Ballerini Chiara¹,Bonavita Simona³,Buscarinu Maria⁴,Calabrese Massimiliano⁵,Cavalla Paola⁶^ORCID,Cellerino Maria⁷,Cordioli Cinzia⁸,Dattola Vincenzo⁹,De Biase Stefano¹⁰,De Meo Ermelinda¹,Fantozzi Roberta¹¹,Gallo Antonio¹²,Iasevoli Luigi¹³,Karabudak Rana¹⁴,Landi Doriana¹⁵,Lorefice Lorena¹⁶,Moiola Lucia¹⁷^ORCID,Ragonese Paolo¹⁸,Ruscica Francesca¹⁹,Sen Sedat²⁰^ORCID,Sinisi Leonardo²¹,Signoriello Elisabetta³^ORCID,Toscano Simona²²²³,Verrengia Elena²⁴,Siva Aksel²⁵^ORCID,Masciulli Camilla¹,Sormani Maria Pia²²⁶^ORCID,Amato Maria Pia¹²⁷^ORCID

Affiliation:

1. Department of NEUROFARBA, University of Florence, Florence, Italy

2. Section of Biostatistics, Department of Health Sciences, University of Genova, Genova, Italy

3. II Division, Department of Neurology, University of Campania Luigi Vanvitelli, Naples, Italy

4. Department of Neurology, Sant’Andrea Hospital, Rome, Italy

5. The Multiple Sclerosis Centre, Department of Neurosciences, Biomedicine and Movement, University Hospital of Verona, Verona, Italy

6. MS Center, Department of Neuroscience, City of Health and Science University Hospital of Turin, Turin, Italy

7. Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy

8. Multiple Sclerosis Center, ASST Spedali Civili di Brescia, Montichiari Hospital, Brescia, Italy

9. MS Center, Bianchi Melacrino Morelli Great Metropolitan Hospital, Reggio Calabria, Italy

10. Neurology Unit, Ospedale dell’Angelo, Venezia Mestre, Italy

11. Department of Neurology, IRCCS Neuromed, Pozzilli, Italy

12. MS Center, I Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy

13. MS Center, Santa Lucia Foundation IRCCS, Rome, Italy

14. Faculty of Medicine, Hacettepe University, Ankara, Turkey

15. MS Center, Tor Vergata University, Rome, Italy

16. Multiple Sclerosis Centre, Binaghi Hospital, ASL Cagliari, University of Cagliari, Cagliari, Italy

17. Multiple Sclerosis Center and Neurology Department IRCCS San Raffaele Hospital, Milan, Italy

18. BIND Department, University of Palermo, Palermo, Italy

19. MS Center, Institute Foundation G. Giglio, Cefalù, Italy

20. School of Medicine, Ondokuz Mayis University, Samsun, Turkey

21. MS Center, S. Paolo Hospital, Naples, Italy

22. Multiple Sclerosis Unit, University Hospital G. Rodolico, Catania, Italy

23. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

24. Multiple Sclerosis Centre, ASST OVEST MI, Legnano Hospital, Legnano, Italy

25. Faculty of Medicine, Cerrahpasa University, Istanbul, Turkey

26. IRCCS Ospedale Policlinico San Martino, Genova, Italy

27. IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy

Abstract

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.

Publisher

SAGE Publications

Link

https://journals.sagepub.com/doi/pdf/10.1177/13524585241232266

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