Urolithiasis in children and exposure to melamine: A review of the epidemiological literature

Abstract

Melamine (ME) is a high production volume compound, mainly used for the synthesis of ME-formaldehyde resins. There is an extensive toxicological and epidemiological database on this compound, but the epidemiology has so far not been reviewed. An extensive literature search in PubMed was conducted and relevant ME epidemiology studies were identified and assessed. The epidemiology data nearly entirely consisted of studies on the health effects due to the food tampering catastrophe in China discovered in 2008 where ME was intentionally added to powdered milk products. Most of these studies were aimed at assessing the extent of the catastrophe and the clinical follow-up of affected children. A reliable dose–response relationship could not be derived from the epidemiology studies. However, they do contain several strong data points that can assist in ranging the No Observed Adverse Effect Level (NOAEL) for humans, for children in particular.