Seasonal predominance of atypical agents in adult community-acquired pneumonia in India's northeastern region: Is it the time to look again at empirical therapy guidelines?

Author:

Kalita Deepjyoti12ORCID,Deka Sangeeta3,Sharma Kripesh Ranjan2,Sarma Ridip Kumar2,Hazarika Naba Kumar2

Affiliation:

1. All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

2. Gauhati Medical College and Hospital, Guwahati, Assam, India

3. Fakharuddin Ali Ahmed Medical Collee, Barpeta, Assam, India

Abstract

Atypical agents such as Mycoplasma, Legionella, Chlamydia species, and Coxiella burnetii (Q-fever agent) are responsible for some adult community-acquired pneumonia (CAP). Insufficient studies on this topic can be blamed for the failure to include atypical pathogens in empirical management. We followed adult CAP cases for two years, and samples (respiratory and serum) were tested by culture, ELISA (IgM, IgG, and IgA), and PCR. A risk factor analysis was performed. Overall in 21.3% adult CAP patients, atypical agents found were Mycoplasma pneumoniae (51.5%), Legionella pneumophila (28.8%), and Chlamydophila pneumoniae (19.7%). However, amongst patients <60 years of age and in the summer season, the proportion of atypical agents increased significantly. There is thus a need to re-examine empirical antibiotic regimes.

Funder

Department of Biotechnology , Ministry of Science and Technology

Publisher

SAGE Publications

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

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