Principles of Risk Assessment

Author:

Clarkson Thomas W.1

Affiliation:

1. Division of Toxicology School of Medicine and Dentistry University of Rochester Rochester, New York 14642

Abstract

_ This review discusses the basic principles of risk assessment as used in general toxicology and in monitoring side-effects of therapeutic treatments. It also outlines how these principles may apply to assessment of biological reactions to dental restorative materials. Mercury exposure from amalgam fillings is used as an example. The calculations performed are intended only as illustrations, and many other factors must be taken into account. Thus, the calculations are not intended as the last word in risk assessment of amalgam fillings.

Publisher

SAGE Publications

Subject

General Medicine

Reference13 articles.

1. The Effect of Dental Amalgam Restorations on Blood Mercury Levels

2. Reference dose (RfD): Description and use in health risk assessments

3. Clarkson TW, Friberg L., Hursh JB, Nylander M. (1988). The prediction of intake of mercury vapor from amalgams. In: Clarkson TW, Friberg L, Nordberg GF, Sager PR, editors. Biological monitoring of toxic metals. New York: Plenum Press, 261.

4. Epa (1989). The Science Advisory Board: making a difference. Director's report fiscal year 1988, issued March, 1989. Washington, DC: Science Advisory Board, Office of the Administrator, United States Environmental Protection Agency, 9.

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