Enhanced Sensitivity to IL-2 Signaling Regulates the Clinical Responsiveness of IL-12–Primed CD8+ T Cells in a Melanoma Model
Author:
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Reference63 articles.
1. Adoptive cell transfer: a clinical path to effective cancer immunotherapy
2. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
3. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells
4. Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity
5. Ex vivo Culture with Interleukin (IL)-12 Improves CD8+ T-Cell Adoptive Immunotherapy for Murine Leukemia Independent of IL-18 or IFN-γ but Requires Perforin
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