A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)-Reference-Cited by-同舟云学术

A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI)

Published:2022-08-30 Issue:5 Volume:18 Page:1399-1403
ISSN:1734-1922
Container-title:Archives of Medical Science
language:
Short-container-title:Arch Med Sci

Author:

Zhang Zhuang¹,Sui Rubo¹,Xia Dongjian²

Affiliation:

1. Department of Neurology, the First Affiliated Hospital, Jinzhou Medical University, Jinzhou, China

2. Department of Neurosurgery, the First Affiliated Hospital of Jinzhou Medical University, China

Abstract

IntroductionIn this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways.Material and methodsFive hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression.ResultsBy luciferase assays, we validated Bcl-2-like protein 11 (BIM) as a target gene of miR-124 with a negative regulatory relationship between them. We also observed that miR-124 suppressed cell viability and accelerated cell apoptosis.Conclusionsrs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.

Publisher

Termedia Sp. z.o.o.

Subject

General Medicine

Link

https://www.archivesofmedicalscience.com/pdf-151683-78031

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