Hemato-biochemical changes during xylazine-ketamine and xylazine-thiopentone anesthesia in dogs

Author:

Munif M. R.1,Alam M. M.1,Alam M. R.1

Affiliation:

1. Department of Surgery and Obstetrics, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh

Abstract

Background: This study was conducted to evaluate certain haemato-biochemical changes during Xylazine-Ketamine (X-K) and Xylazine-Thiopentone (X-T) anesthesia in dogs. Methods: For this, six dogs of 18 to 25 kg BW were selected and divided into two groups: Group I (X-K) and Group II (X-T). Atropine sulfate @ 0.05 mg/kg BW (IM) was used for premedication in both groups. Dogs in Group I (n=3) were anaesthetized with Xylazine HCl @ 1.1 mg/kg BW (IM) and Ketamine HCl @ 5.5 mg/kg BW (IM), whereas Xylazine HCl @ 1.1mg/kg BW (IM) and Thiopentone sodium @ 20 mg/kg BW (IV) were used for anesthesia in Group II (n=3). In both groups, peripheral blood samples were collected from the dogs before induction of anesthetic agents (control) and thereafter on 10, 20, 30, and 40 minutes of post-induction and again after complete recovery from anesthesia to evaluate hematological changes in Total Erythrocyte Count (TEC), Haemoglobin (Hb) and Packed Cell Volume (PCV). In addition, serum biochemical changes in Total Serum Protein (TSP), Blood Urea Nitrogen (BUN), Creatinine, Sodium (Na), Potassium (K), and Chloride (Cl) were also assessed in both groups. Results: TEC, Hb, and PCV were altered significantly (P<0.05) in most of the cases, TSP was decreased significantly (P<0.05) but BUN was increased significantly (P<0.05), and creatinine was also increased in both groups during the experiment. There were mild alterations in Na, K, and Cl values after induction, and found near to the baseline (control) after recovery. Conclusions: These findings ascertained that the anesthetic combinations of X-K and X-T assert some definite haemato-biochemical changes in dogs which should be carefully judged by the veterinarians during surgical interventions to avoid anesthesia-related risks and complications.

Publisher

Bangladesh Society for Veterinary Medicine

Reference43 articles.

1. 1. Anandmay AK, Dass LL, Sharma AK, Gupta MK. Haemato-biochemical changes following administration of propofol in combination with buprenorphine in atropinized dogs. Journal of Animal Research. 2016; 6(3): 531–536.

2. 2. Bond AG, Parsons RS. Haemodilution and plasma proteins during anaesthesia. British Journal of Anaesthesia. 1970; 42(1): 1113–1118.

3. 3. Brodbelt DC, Hammond R, Tuminaro D. Risk factors for anesthetic–related death in referred dogs. Veterinary Record. 2006; 158(1): 563–564.

4. 4. Butola V, Singh B. Haemato-biochemical effects of midazolam and ketamine anaesthesia in dogs. Indian Journal of Veterinary Surgery. 2003; 24(1): 44–45.

5. 5. Chitale DK, Pratap AK, Singh GR, Gupta OP. Biochemical effects of ketamine with premedication of alpha-2 agonists and diazepam in goats. The Indian Veterinary Journal. 1999; 76(4): 304–305.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3