Assessment of the Antibiotic Resistance Characteristics of Staphylococcus aureus Isolated at Da Nang Hospital for Women and Children, Vietnam

Abstract

Background: Infections caused by multidrug-resistant Staphylococcus aureus (S. aureus), typically from methicillin-resistant S. aureus (MRSA) have become a global problem, including Vietnam. Objectives: To assess the prevalence of S. aureus infections, pathogenic characteristics, and evaluate antibiotic resistance profiles. Methods: This was a cross-sectional descriptive study of 191 S. aureus isolates cultured from clinical samples with antibiotic resistance profiles at the Department of Microbiology, Da Nang Hospital for Women and Children, Vietnam, from July 2021 to September 2022. Strain identification and susceptibility tests were performed by using an AST-GP Card in VITEK 2 Compact. Results: The proportion of S. aureus infection was high in females (56.02%) and children under 6 years (65.97%). The major clinical sample of S. aureus was pus (63.87%) and most commonly isolated in the Outpatient Department (31.41%). S. aureus showed resistance to over 70.00% of the antibiotics in group A, with lower resistance (1.05% - 48.69%) towards those in groups B and C. The rates of isolation of vancomycin-resistant S. aureus and vancomycin-intermediate S. aureus were 1.57% and 1.05%, respectively, but no isolates resistant to linezolid was found. The proportion of MRSA was found to be 78.01%. Prevalence of multidrug-resistance MRSA (MDR-MRSA) was markedly high (79.87%). Conclusions: The presence of S. aureus with varying antibiotic sensitivity patterns was found, as well as multidrug resistance. The prevalence of MRSA and MDR-MRSA was noticeable in this study.