THE EVALUATION OF THE EFFECT OF THE TREATMENTS ON OXIDATIVE STRESS AND INFLAMMATION IN PATIENTS RECEIVING DIFFERENT DIALYSIS MODALITIES

Author:

KOYUNCU Sümeyra1ORCID,SİPAHİOĞLU Hilal1ORCID,KOÇYİĞİT İsmail2ORCID,OYMAK Oktay2ORCID,TOKGÖZ Bülent2ORCID,SİPAHİOĞLU Murat2ORCID

Affiliation:

1. SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KAYSERİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ

2. ERCIYES UNIVERSITY

Abstract

ABSTRACT Aim: To evaluate the effects of different dialysis methods on oxidative stress and inflammation in patients with end-stage renal disease (ESRD) who are newly enrolled in a routine dialysis program. Material and Methods: In this prospective study, 138 ESRD patients and 30 healthy volunteers were evaluated. Fifty-four of 73 hemodialysis (HD) patients and 51 of 65 periton dialysis (PD) patients completed the study. Other patients were excluded from the study. The levels of superoxide dismutase (SOD) and total antioxidant capacity (TAC) were measured to determine the oxidative stress status, and IL-6, IL-10, and F2 isoprostane levels were measured to determine the inflammation status, just before the start of dialysis treatment and at 6 months. Results: At the beginning of the study, hs-CRP and IL-6 levels were significantly higher in the patient group compared to the control group (p

Publisher

Cagdas Tip Dergisi: Journal of Contemporary Medicine

Subject

General Medicine

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