Abstract
Objective: To evaluate the association of vitamin D deficiency with hepatitis B and C virus Infection.
Study Design: This is a prospective study.
Setting: Study carried out at Medicine department Civil Hospital Karachi, from March, 2018 to December, 2019.
Materials and Methods: 266 Participants of the study included patients with active hepatitis B or hepatitis C infection visiting OPD of the hospital. Vitamin D levels of 14-30 ng/ml have been described as insufficient and levels <14 ng/ml are labelled as deficient. Vitamin D level of >30 nm/ml have been defined as sufficient according to our study. Diagnosis of Hepatitis B is confirmed by HBV DNA and HBsAg serum levels and of Hepatitis C by HCV RNA levels.
Results: We received 70.6% (n=266) males and 29.3% females. After serological tests 34.9% (n=93) patients were positive for HBV DNA whereas 47.7% (n=127) patients were positive for HCV DNA. Coinfection with hepatitis B and C was present in 17.2% (n=46) of patients. Amongst total 266 participants 54.31% patients have been vitamin D deficient and 32.7% have insufficient vitamin D levels.
Conclusion: Genetic and metabolic factors linked to hepatitis B and C with vitamin D deficiency should be studied on large scale. In our study patients infected with HBV and HCV have been vitamin D deficient, supplementation needs to be added to the treatment regimen.
Publisher
Sciencedomain International
Cited by
1 articles.
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