Sample treatment based on extraction techniques in biological matrices

Author:

Ashri Nadia Y1,Abdel-Rehim Mohamed234

Affiliation:

1. Najd Consulting Hospital, PO Box 123251, Riyadh, Kingdom of Saudi Arabia

2. Clinical Pharmacology & DMPK, AstraZeneca R&D Södertälje, SE-151 85 Södertälje, Sweden.

3. Department of Chemistry & Biomedical Sciences, Karlstad University, SE-65188 Karlstad, Sweden

4. Department of Analytical Chemistry, Stockholm University, SE-10691 Stockholm, Sweden

Abstract

The importance of sample preparation methods as the first stage in bioanalysis is described. In this article, the sample preparation concept and strategies will be discussed, along with the requirements for good sample preparation. The most widely used sample preparation methods in the pharmaceutical industry are presented; for example, the need for same-day rotation of results from large numbers of biological samples in pharmaceutical industry makes high throughput bioanalysis more essential. In this article, high-throughput sample preparation techniques are presented; examples are given of the extraction and concentration of analytes from biological matrices, including protein precipitation, solid-phase extraction, liquid–liquid extraction and microextraction-related techniques. Finally, the potential role of selective extraction methods, including molecular imprinted phases, is considered.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

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