Calcium complexes of oxicams: new dimensions in rheumatoid arthritis treatment

Author:

Sadia Aatika12,Yasmin Tahira1,Imran Muhammad3,Samra Malka M1,Raza Basra Muhammad Asim1ORCID

Affiliation:

1. Centre for Clinical & Nutritional Chemistry, School of Chemistry, University of the Punjab, New Campus, Lahore, 54590, Pakistan

2. Department of Science & Technology, Laboratory of Organic Electronics, Linköping University, Norrköping, 60174, Sweden

3. Centre for Inorganic Chemistry, School of Chemistry, University of the Punjab, New Campus, Lahore, 54590, Pakistan

Abstract

Various metals have been complexed with drugs to improve their cellular impact. Inflammatory diseases like rheumatoid arthritis (RA) are characterized by unbalanced production of proinflammatory cytokines (PICs) and prostaglandins with decreased levels of vitamin D and calcium. The inflammation can be suppressed through targeting the formation of PICs or related enzymes by various treatment strategies that involve the use of corticosteroids, disease-modifying antirheumatic drugs and NSAIDs. We present a detailed review on the impact of calcium complexes of oxicams as an advanced treatment strategy for RA. The calcium complexes demonstrate promising capabilities to cure the disease, improve the strength of bones and suppress PICs in RA.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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