Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies-Reference-Cited by-同舟云学术

Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies

Published:2023-03 Issue:5 Volume:15 Page:421-436
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Shehta Wael¹^ORCID,Agili Fatimah²,Farag Basant¹,Said Said A¹,Youssif Shaker¹^ORCID,Abdraboh Mohamed E³,El-Kalyoubi Samar⁴^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

2. Department of Chemistry, Faculty of Science (Female Section), Jazan University, Jazan, 82621, Saudi Arabia

3. Department of Zoology, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

4. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, 42511, Egypt

Abstract

Aim: Synthesis of novel pyran-based uracils that may have potent antitumor activity against hepatocellular carcinoma HepG2 and ovarian cancer SKOV3 cell lines. Materials & methods: Novel pyran-based uracils were synthesized and their anticancer activity was assessed using methyl thiazolyl tetrazolium and wound-healing assays to detect their cytotoxicity and their antiproliferative and antimigratory activities. Results: Compounds 3, 5, 6, 7, 8, 9, 10, 11 and 13 significantly inhibited cell proliferation of the HepG2 cell line. Compounds 7, 8, 9 and 13 significantly inhibited the proliferation of SKOV3 cells, which was also proven through docking studies with topoisomerase I. Conclusion: The molecular docking analysis revealed that 7 and 9 are two major compounds found to possess higher degrees of interaction with DNA gyrase.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2022-0279

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