The role of microRNA-21 in the onset and progression of cancer-Reference-Cited by-同舟云学术

The role of microRNA-21 in the onset and progression of cancer

Published:2021-11 Issue:21 Volume:13 Page:1885-1906
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Singh Ashutosh¹^ORCID,Singh Ashutosh Kumar¹,Giri Rajanish¹^ORCID,Kumar Dhruv²^ORCID,Sharma Rohit³^ORCID,Valis Martin⁴,Kuca Kamil⁵^ORCID,Garg Neha⁶^ORCID

Affiliation:

1. School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh, 175005, India

2. Amity Institute of Molecular Medicine & Stem Cell Research, Noida, 201303, India

3. Department of Rasa Shastra & Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

4. Department of Neurology, Faculty of Medicine in Hradec Kralove & University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, 50003, Czech Republic

5. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50005, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, 50005, Czech Republic

6. Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

Abstract

MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the expression of genes. Aberrant expression of miRNA is reported in various types of cancer. Since the first report of oncomiR-21 involvement in the glioma, its upregulation was reported in multiple cancers and was allied with high oncogenic property. In addition to the downregulation of tumor suppressor genes, the miR-21 is also associated with cancer resistance to various chemotherapy. The recent research is appraising miR-21 as a promising cancer target and biomarker for early cancer detection. In this review, we briefly explain the biogenesis and regulation of miR-21 in cancer cells. Additionally, the review features the assorted genes/pathways regulated by the miR-21 in various cancer and cancer stem cells.

Funder

Science and Engineering Research Board grant, India

UHK project

Seed grant under Institute of Eminence Scheme

Ministry of Health of the Czech Republic

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2021-0096

Reference206 articles.