Advances in metabolite identification

Author:

Wishart David S1

Affiliation:

1. Departments of Computing Science & Biological Sciences, University of Alberta, Edmonton, AB, T6G 2E8 Canada and National Institute for Nanotechnology, 11421 Saskatchewan Drive, Edmonton, AB, T6G 2M9 Canada.

Abstract

One of the central challenges to metabolomics is metabolite identification. Regardless of whether one uses so-called ‘targeted’ or ‘untargeted’ metabolomics, eventually all paths lead to the requirement of identifying (and quantifying) certain key metabolites. Indeed, without metabolite identification, the results of any metabolomic analysis are biologically and chemically uninterpretable. Given the chemical diversity of most metabolomes and the character of most metabolomic data, metabolite identification is intrinsically difficult. Consequently a great deal of effort in metabolomics over the past decade has been focused on making metabolite identification better, faster and cheaper. This review describes some of the newly emerging techniques or technologies in metabolomics that are making metabolite identification easier and more robust. In particular, it focuses on advances in metabolite identification that have occurred over the past 2 to 3 years concerning the technologies, methodologies and software as applied to NMR, MS and separation science. The strengths and limitations of some of these approaches are discussed along with some of the important trends in metabolite identification.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

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