Nonhuman targets in allergic lung conditions

Author:

Robinson Clive1,Zhang Jihui2,Newton Gary K3,Perrior Trevor R3

Affiliation:

1. Division of Biomedical Sciences, St George’s, University of London, UK.

2. Division of Biomedical Sciences, St George’s, University of London, UK

3. Domainex Ltd, 162 Cambridge Science Park, Milton Road, Cambridge, UK

Abstract

Existing therapies for allergic asthma are far from perfect: the global prevalence of disease increases despite them and they are poorly effective in dealing with the exacerbations that account for hospitalization and asthma deaths. Commercially, there are pressures on these existing medicines too – a growing threat from generics and reluctance by payers to reimburse for increasingly marginal improvements in medicines with precedented mechanisms. Experience shows that attempts to devise selective small-molecule interventions directed at the myriad of downstream effector pathways has not been a fertile ground for the development of effective new medicines. An alternative strategy, exploiting breakthroughs in understanding the molecular basis of allergenicity and the key role of innate immune mechanisms in asthma, is to direct new approaches to the disease triggers themselves: allergens. This raises interesting possibilities for anti-Lipinski drug design (extracellular nonhuman targets, inhaled delivery) and creates unprecedented pharmacological opportunities in the therapeutic area.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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