Formulation and evaluation of itraconazole-loaded nanoemulgel for efficient topical delivery to treat fungal infections

Abstract

Aim: The clinical application of conventional oral dosage form of itraconazole is limited due to its poor bioavailability. The aim of the study was to develop nanoemulgel of Itraconazole for topical delivery. Method: Nanoemulsions were prepared, optimized and further incorporated into a gel and evaluated for homogeneity, pH, viscosity, spreadability, in vitro drug release and skin irritation studies. Results: Cumulative drug release from nanoemulsions was within the range of 37.24 to 47.63% at 10 h. Drug release % for all the nanoemulgel formulations at10 h was 32.39, 39.75 and 45.9% respectively. Nanoemulgel was non-irritant as demonstrated by skin irritation studies in animals. Conclusion: Itraconazole nanoemulgels were proved to be potential for effective topical delivery of drug with enhanced bioavailability.