Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?

Author:

Siddiqui Ruqaiyyah12ORCID,Yee Ong Timothy Yu3,Maciver Sutherland4,Khan Naveed Ahmed2ORCID

Affiliation:

1. College of Arts & Sciences, American University of Sharjah, Sharjah – United Arab Emirates

2. Microbiota Research Center, Istinye University, Istanbul, 34010, Turkey

3. Department of Biological Sciences, School of Science & Technology, Sunway University, Bandar Sunway, Malaysia

4. Centre for Discovery Brain Sciences, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, UK

Abstract

Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood–brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood–brain barrier selectivity and achieve the minimum inhibitory concentration at the target site.

Funder

Sunway University

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

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