Novel polysaccharides–bile acid–cyclodextrin gel systems and effects on cellular viability and bioenergetic parameters

Author:

Kovacevic Bozica1ORCID,Ionescu Corina Mihaela1ORCID,Jones Melissa1ORCID,Wagle Susbin Raj1ORCID,Foster Thomas1ORCID,Lewkowicz Michael1ORCID,Wong Elaine YM2ORCID,Ðanić Maja3ORCID,Mikov Momir3ORCID,Mooranian Armin1ORCID,Al-Salami Hani1ORCID

Affiliation:

1. The Biotechnology & Drug Development Research Laboratory, Curtin Medical School & Curtin Health Innovation Research Institute, Curtin University, Bentley, Perth, WA 6102, Australia

2. Hearing Therapeutics, Ear Science Institute Australia, Queen Elizabeth II Medical Centre, Nedlands, Perth, WA 6009, Australia

3. Department of Pharmacology, Toxicology & Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, 21101, Serbia

Abstract

Aim: The novel hydrogel systems made from sodium alginate, pectin, beta-cyclodextrin and deoxycholic acid (DCA) were proposed as potential drug-delivery matrices. Materials & methods: To ensure biocompatibility, rheological parameters were examined and hydrogels' effects on bioenergetic parameters and cellular viability on murine hepatic, and muscle and pancreatic beta cells. Results & conclusion: All hydrogels show non-Newtonian, shear thinning behavior. Cells displayed various oxygen-dependent viability patterns, with the bile acid overall adversely affecting their biological activities. All cells performed best under normoxia, with pancreatic beta cells displaying the most profound oxygen-dependent viability behavior. The cells tolerated the addition of a moderate concentration of beta-cyclodextrin to the polymer matrix.

Publisher

Informa UK Limited

Subject

Pharmaceutical Science

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