Advances in delivery vectors for gene therapy in liver cancer

Author:

Redd Bowman Katherine E1,Lu Phong1,Vander Mause Erica R1,Lim Carol S1

Affiliation:

1. Department of Pharmaceutics & Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA

Abstract

Hepatocellular carcinoma (HCC) is the third most common cause of cancer death globally, mainly due to lack of effective treatments – a problem that gene therapy is poised to solve. Successful gene therapy requires safe and efficient delivery vectors, and recent advances in both viral and nonviral vectors have made an important impact on HCC gene therapy delivery. This review explores how adenoviral, retroviral and adeno-associated viral vectors have been modified to increase safety and delivery capacity, highlighting studies and clinical trials using these vectors for HCC gene therapy. Nanoparticles, liposomes, exosomes and virosomes are also featured in their roles as HCC gene delivery vectors. Finally, new discoveries in gene editing technology and their impacts on HCC gene therapy are discussed.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Reference164 articles.

1. The p53 family in hepatocellular carcinoma

2. Institute NC. Cancer stat facts: Liver and intrahepatic bile duct cancer (2019). https://seer.cancer.gov/statfacts/html/livibd.html

3. Hepatocellular carcinoma: From diagnosis to treatment

4. Results of 15-Year Experience in Liver Transplant for Hepatocellular Carcinoma

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