Systems genetics approaches for understanding complex traits with relevance for human disease

Author:

Allayee Hooman12ORCID,Farber Charles R345ORCID,Seldin Marcus M6ORCID,Williams Evan Graehl7ORCID,James David E8910ORCID,Lusis Aldons J111213ORCID

Affiliation:

1. Departments of Population & Public Health Sciences, University of Southern California

2. Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California

3. Center for Public Health Genomics, University of Virginia School of Medicine

4. Departments of Biochemistry & Molecular Genetics, University of Virginia School of Medicine

5. Public Health Sciences, University of Virginia School of Medicine

6. Department of Biological Chemistry, University of California, Irvine

7. Luxembourg Centre for Systems Biomedicine, University of Luxembourg

8. School of Life and Environmental Sciences, University of Sydney

9. Faculty of Medicine and Health, University of Sydney

10. Charles Perkins Centre, University of Sydney

11. Departments of Human Genetics, University of California, Los Angeles

12. Medicine, University of California, Los Angeles

13. Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine of UCLA

Abstract

Quantitative traits are often complex because of the contribution of many loci, with further complexity added by environmental factors. In medical research, systems genetics is a powerful approach for the study of complex traits, as it integrates intermediate phenotypes, such as RNA, protein, and metabolite levels, to understand molecular and physiological phenotypes linking discrete DNA sequence variation to complex clinical and physiological traits. The primary purpose of this review is to describe some of the resources and tools of systems genetics in humans and rodent models, so that researchers in many areas of biology and medicine can make use of the data.

Funder

National Institutes of Health

Australian Research Council

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Special Issue “Deployment of Proteomics Approaches in Biomedical Research”;International Journal of Molecular Sciences;2024-01-31

2. Genetics unravels protein–metabolite relationships;Trends in Endocrinology & Metabolism;2024-01

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