Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses

Author:

Bang Jee Yoon1ORCID,Sunstrum Julia Kathryn2,Garand Danielle1,Parfitt Gustavo Morrone34ORCID,Woodin Melanie1ORCID,Inoue Wataru2ORCID,Kim Junchul14ORCID

Affiliation:

1. Cell and Systems Biology, University of Toronto

2. Robarts Research Institute, Western University

3. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai

4. Psychology, University of Toronto

Abstract

Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviors.

Funder

Canadian Institute of Health Research

NSERC Discovery

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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