A split-GAL4 driver line resource for Drosophila CNS cell types-Reference-Cited by-同舟云学术

A split-GAL4 driver line resource for Drosophila CNS cell types

Published:2024-07-30 Issue: Volume: Page:
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Author:

Meissner Geoffrey W¹^ORCID,Vannan Allison¹,Jeter Jennifer¹,Close Kari¹,DePasquale Gina M¹,Dorman Zachary¹^ORCID,Forster Kaitlyn¹,Beringer Jaye Anne¹,Gibney Theresa V¹,Hausenfluck Joanna H¹,He Yisheng¹,Henderson Kristin¹^ORCID,Johnson Lauren¹,Johnston Rebecca M¹,Ihrke Gudrun¹^ORCID,Iyer Nirmala¹,Lazarus Rachel¹,Lee Kelley¹,Li Hsing-Hsi¹^ORCID,Liaw Hua-Peng¹^ORCID,Melton Brian¹,Miller Scott¹,Motaher Reeham¹,Novak Alexandra¹,Ogundeyi Omotara¹^ORCID,Petruncio Alyson¹,Price Jacquelyn¹,Protopapas Sophia¹,Tae Susana¹,Taylor Jennifer¹,Vorimo Rebecca¹,Yarbrough Brianna¹,Zeng Kevin Xiankun¹,Zugates Christopher T¹^ORCID,Dionne Heather¹,Angstadt Claire¹,Ashley Kelly¹,Cavallaro Amanda¹^ORCID,Dang Tam¹,Gonzalez Guillermo A¹,Hibbard Karen L¹^ORCID,Huang Cuizhen¹,Kao Jui-Chun¹,Laverty Todd¹,Mercer Monti¹,Perez Brenda¹^ORCID,Pitts Scarlett¹,Ruiz Danielle¹,Vallanadu Viruthika¹,Zheng Grace Zhiyu¹,Goina Cristian¹^ORCID,Otsuna Hideo¹^ORCID,Rokicki Konrad¹^ORCID,Svirskas Robert R¹^ORCID,Cheong Han SJ¹^ORCID,Dolan Michael-John¹,Ehrhardt Erica¹²^ORCID,Feng Kai¹³^ORCID,El Galfi Basel¹,Goldammer Jens¹²^ORCID,Huston Stephen J¹⁴^ORCID,Hu Nan¹,Ito Masayoshi¹¹,McKellar Claire¹^ORCID,Minegishi Ryo¹²^ORCID,Namiki Shigehiro¹^ORCID,Nern Aljoscha¹^ORCID,Schretter Catherine E¹^ORCID,Sterne Gabriella R¹⁵^ORCID,Venkatasubramanian Lalanti¹,Wang Kaiyu¹,Wolff Tanya¹^ORCID,Wu Ming¹^ORCID,George Reed¹,Malkesman Oz¹^ORCID,Aso Yoshinori¹^ORCID,Card Gwyneth M¹^ORCID,Dickson Barry J¹³^ORCID,Korff Wyatt¹^ORCID,Ito Kei¹²^ORCID,Truman James W¹,Zlatic Marta¹,Rubin Gerald M¹^ORCID,

Affiliation:

1. Janelia Research Campus, Howard Hughes Medical Institute

2. Institute of Zoology, University of Cologne

3. Queensland Brain Institute, University of Queensland

4. Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University

5. Department of Cell & Molecular Biology, University of California

Abstract

Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types in Drosophila melanogaster and other species. We describe here a collection of 3060 lines targeting a range of cell types in the adult Drosophila central nervous system and 1373 lines characterized in third-instar larvae. These tools enable functional, transcriptomic, and proteomic studies based on precise anatomical targeting. NeuronBridge and other search tools relate light microscopy images of these split-GAL4 lines to connectomes reconstructed from electron microscopy images. The collections are the result of screening over 77,000 split hemidriver combinations. In addition to images and fly stocks for these well-characterized lines, we make available 300,000 new 3D images of other split-GAL4 lines.

Publisher

eLife Sciences Publications, Ltd

Link

https://elifesciences.org/reviewed-preprints/98405v1/pdf

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