Affiliation:
1. Institute of Neuroscience and Medicine, Brain and Behaviour, Research Centre Jülich
2. Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf
3. Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences
4. McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University
Abstract
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and receptor molecules, is a relevant component of structure–function relationships in the human brain. Here, we studied the organization of the receptome, a measure of interareal chemoarchitectural similarity, derived from positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors. Nonlinear dimensionality reduction revealed three main spatial gradients of cortical chemoarchitectural similarity – a centro-temporal gradient, an occipito-frontal gradient, and a temporo-occipital gradient. In subcortical nuclei, chemoarchitectural similarity distinguished functional communities and delineated a striato-thalamic axis. Overall, the cortical receptome shared key organizational traits with functional and structural brain anatomy, with node-level correspondence to functional, microstructural, and diffusion MRI-based measures decreasing along a primary-to-transmodal axis. Relative to primary and paralimbic regions, unimodal and heteromodal regions showed higher receptomic diversification, possibly supporting functional flexibility.
Funder
Max-Planck-Institut für Kognitions- und Neurowissenschaften
Helmholtz International BigBrain Analytics & Laboratory
Natural Sciences and Engineering Research Council of Canada
Canadian Institutes of Health Research
Brain Canada Foundation Future Leaders Fund
Canada Research Chairs
Michael J. Fox Foundation for Parkinson's Research
Sick Kids Foundation
Azrieli Center for Autism Research
Fonds de Recherche du Québec - Santé
Tier-2 Canada Research Chairs program
Human Brain Project
Helmholtz International Lab grant agreement
Canada First Research Excellence Fund
Horizon 2020
Max Planck Society
Publisher
eLife Sciences Publications, Ltd
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Cited by
4 articles.
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