Competing neural representations of choice shape evidence accumulation in humans

Author:

Bond Krista123ORCID,Rasero Javier1,Madan Raghav4ORCID,Bahuguna Jyotika1ORCID,Rubin Jonathan25ORCID,Verstynen Timothy1236ORCID

Affiliation:

1. Department of Psychology, Carnegie Mellon University

2. Center for the Neural Basis of Cognition

3. Carnegie Mellon Neuroscience Institute

4. Department of Biomedical and Health Informatics, University of Washington

5. Department of Mathematics, University of Pittsburgh

6. Department of Biomedical Engineering, Carnegie Mellon University

Abstract

Making adaptive choices in dynamic environments requires flexible decision policies. Previously, we showed how shifts in outcome contingency change the evidence accumulation process that determines decision policies. Using in silico experiments to generate predictions, here we show how the cortico-basal ganglia-thalamic (CBGT) circuits can feasibly implement shifts in decision policies. When action contingencies change, dopaminergic plasticity redirects the balance of power, both within and between action representations, to divert the flow of evidence from one option to another. When competition between action representations is highest, the rate of evidence accumulation is the lowest. This prediction was validated in in vivo experiments on human participants, using fMRI, which showed that (1) evoked hemodynamic responses can reliably predict trial-wise choices and (2) competition between action representations, measured using a classifier model, tracked with changes in the rate of evidence accumulation. These results paint a holistic picture of how CBGT circuits manage and adapt the evidence accumulation process in mammals.

Funder

Air Force Research Laboratory

National Institutes of Health

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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