Myomatrix arrays for high-definition muscle recording

Author:

Chung Bryce1,Zia Muneeb2,Thomas Kyle A3,Michaels Jonathan A4ORCID,Jacob Amanda1,Pack Andrea5,Williams Matthew J3,Nagapudi Kailash1,Teng Lay Heng1,Arrambide Eduardo1,Ouellette Logan1,Oey Nicole1,Gibbs Rhuna1,Anschutz Philip6,Lu Jiaao7ORCID,Wu Yu2,Kashefi Mehrdad4ORCID,Oya Tomomichi4ORCID,Kersten Rhonda4,Mosberger Alice C8ORCID,O'Connell Sean3,Wang Runming9,Marques Hugo10ORCID,Mendes Ana Rita10,Lenschow Constanze10,Kondakath Gayathri11,Kim Jeong Jun12,Olson William12,Quinn Kiara N13,Perkins Pierce13,Gatto Graziana14ORCID,Thanawalla Ayesha14,Coltman Susan15,Kim Taegyo16,Smith Trevor16,Binder-Markey Ben17ORCID,Zaback Martin18,Thompson Christopher K18,Giszter Simon16,Person Abigail1519ORCID,Goulding Martyn14,Azim Eiman14ORCID,Thakor Nitish13,O'Connor Daniel12,Trimmer Barry11,Lima Susana Q10,Carey Megan R10ORCID,Pandarinath Chethan9,Costa Rui M8ORCID,Pruszynski J Andrew4ORCID,Bakir Muhannad2,Sober Samuel J1ORCID

Affiliation:

1. Department of Biology, Emory University

2. School of Electrical and Computer Engineering, Georgia Institute of Technology

3. Graduate Program in Biomedical Engineering at Emory University and Georgia Tech

4. Department of Physiology and Pharmacology, Western University

5. Neuroscience Graduate Program, Emory University

6. Graduate Program in BioEngineering, Georgia Tech

7. Graduate Program in Electrical and Computer Engineering, Georgia Tech

8. Zuckerman Mind Brain Behavior Institute at Columbia University

9. Department of Biomedical Engineering at Emory University and Georgia Tech

10. Champalimaud Neuroscience Programme, Champalimaud Foundation

11. Department of Biology, Tufts University

12. Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine

13. Departments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine

14. Salk Institute for Biological Studies

15. Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus

16. Department of Neurobiology & Anatomy, Drexel University, College of Medicine

17. Department of Physical Therapy and Rehabilitation Sciences, Drexel University College of Nursing and Health Professions

18. Department of Health and Rehabilitation Sciences, Temple University

19. Allen Institute

Abstract

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system’s actual motor output – the activation of muscle fibers by motor neurons – typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices (‘Myomatrix arrays’) that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a ‘motor unit,’ during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system’s motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and identifying pathologies of the motor system.

Funder

National Institute of Neurological Disorders and Stroke

European Research Council

Simons Foundation

Deutsche Forschungsgemeinschaft

Halle Institute for Global Research, Emory University

Human Frontier Science Program

European Regional Development Fund

Fundação para a Ciência e a Tecnologia

Banting Research Foundation

Canada First Research Excellence Fund

Vector Institute

Swiss National Science Foundation

National Institute of Mental Health

Defense Advanced Research Projects Agency

National Science Foundation

National Institutes of Health

Alfred P. Sloan Foundation

Canadian Institutes of Health Research

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

National Institute of Biomedical Imaging and Bioengineering

McKnight Foundation

Kavli Foundation

Azrieli Foundation

Novo Nordisk Fonden

Johns Hopkins

Salk Institute

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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