Cell non-autonomous regulation of health and longevity

Author:

Miller Hillary A1ORCID,Dean Elizabeth S2,Pletcher Scott D2ORCID,Leiser Scott F23ORCID

Affiliation:

1. Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, United States

2. Molecular & Integrative Physiology Department, University of Michigan, Ann Arbor, United States

3. Department of Internal Medicine, University of Michigan, Ann Arbor, United States

Abstract

As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism’s ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging fromC. elegansto mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics.

Funder

National Institutes of Health

National Science Foundation

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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