Affiliation:
1. Department of Pharmacology, Faculty of Pharmacy, Oriental University, Indore.
Abstract
Aim: The Present studies were evaluate antianxiety activity of methanolic composite leaves extract of (Zingiber officinale, Azadirachta indica, Curcuma longa and Hibiscus rosasinesis) on administration in rats. Method: Male albino Wistar rat were taken and divided into 5 groups and each group contain 4 rats. Diazepam (1mg/kg) and composite extract (50mg/kg, 75mg/kg and 150mg/kg) were suspended in water and administrate orally. In these studies vehicle/ drugs were given 30min before exposure to experimental model such as actophometer and rotarod. C.E increase locometry actvity and time taken by rat to falling from the rod in actophometer and rotarod. The activity of rat is compared with standard drugs diazepam (1mg/kg). Result: The studied shown that at dose of 50mg/kg, 75mg/kg and 150mg/kg composite extract posse’s significant antidepressant activity.