Nanoparticulate Drug Delivery: A Promising Drug Delivery for Protein Drug

Abstract

Protein drugs are the biological drug which cannot be administered orally due to problems related to degradation of protein complex in the acidic and protease-rich environment of the gastrointestinal (GI) tract. High molecular weight of protein drugs often results in poor absorption into the periphery when administered orally. Thus, generally protein drugs administered by injection. Most of the proteins drug have a short serum half-life which need to be administered frequently or in high doses to achieve the therapeutic effectiveness. Frequent dosing of these drugs by injection make patient uncomfortable and cumulative doses also may produce severe side effect due to unspecific binding of drug to non-targeted tissue. So, these difficulties in the administration of protein drugs provides the motivation for preparation of novel drug delivery systems (DDSs) In which drug will protect form biological and chemical degradation in the body and able to release drug for long time after oral administration. Encapsulation of proteins drug in a polymeric nanoparticle has been a widely investigated technology for protein drug delivery. Some ligand enhances the penetration of nanoparticles across the intestinal epithelial cell thus the ligand conjugated polymer can use to enhance the penetration of protein drug across the intestine.