Evaluation of Analgesic activity of Schiff base Coumarins with metal complex

Abstract

Purpose: The metal complexes of schiff bases have essential task during the field of chemistry and possess diverse pharmacological activities. Coumarin containing synthesized derivatives or plant extract may show analgesic effects Objective: Evaluating the analgesic activity of schiff base coumarins with metal complex. Materials and Methods: The study was conducted using Wister rats (150-250g) in both central and peripheral screening models of analgesics such as hot plate method, tail flick method (central) and writhing test (peripheral). The rats were pre administered with different derivatives of coumarins such as copper complex of schiff base of 2,5-dimethoxybenzaldehyde (Compound I), copper complex of schiff base of 4-dimethylaminobenzaldehyde (Compound II) and copper complex of the schiff base of 3-nitrobenzaldehyde (Compound III) for 14 days orally at the dose of 200mg/kg. Body weight, food and water consumption were continuously noted in chronic model. After the fourteen days rats were subjected to different screening models of pain and noted the reaction time. Gastro intestinal (GI) histopathological study was carried out to evaluate the GI toxicity. Results: Pretreatment with the different coumarin derivatives showed analgesic effect by increasing the reaction time to pain. In hot plate method, Compound II and III exhibited significant analgesic activity compared to Compound I whereas all three compounds showed significant increase in reaction time for tail flick method. In writhing test all compounds showed significant activity by reducing the pain perception induced by acetic acid. In histopathological study all compounds showed protective effect by reducing the ulceration and congestion of gastric mucosa. Conclusion: The screening model results and histopathological data evidently substantiate the analgesic effect of schiff base coumarins with metal complex.