Formulation and Characterization of Gastroretentive Drug Delivery System of Teneligliptin

Abstract

The aim of the study is an attempt to prepare and characterize the Teneligliptin floating tablets. Drugs having a short half life are eliminated quickly from the blood circulation. Several controlled delivery systems have been designed which can overcome the problems of unpredictable gastric emptying due to physiological problems and presence of food and also release the drug to maintain its plasma concentration for a longer period of time. The Teneligliptin a orally administered of BCS class-2 drug, which has low solubility and high permeability, which is widely use in the management of type 2 diabetes, is an oral anti- hyperglycemic agent, shows incomplete absorption from the gastrointestinal tract and from the gastrointestinal track and absolute bioavailability is 40-70%. This has to development of oral gastro retentive floating dosage forms.Teneligliptin is a DPP4 inhibitor and is to exert its mechanism of action on management of Type 2 Diabetes mellitus. Teneligliptin is poorly soluble in acidic environment and hence the absorption of drug to diabetic patient is slow due to this gastric motility and emptying capacity.Thus it can be converted into a suitable dosage form like Floating Drug Delivery System. Around 10 formulations were prepared and are characterized by various pre compression and post compression evaluation studies. The preformulation results of Angle of repose, Bulkdensity, Tapped density, Compressibility index, and Hausner’s ratio were found to be within pharmacopoeial limit.The post compression evaluation results of all formulation were within the pharmacopeial limit. The present study revealed that the Teneligliptin can be formulated to enhance the bioavailability which can reduce the frequency of dose.