The Spectral Study and Biological Activity for Azo-Shiff Bases Derivatives containing Pyrimidine Ring

Abstract

The importance of Schiff's bases is that they are used as anti-bacterial, tuberculosis, cancer and tumors, as well as their ability to capture metal ions. Schiff's bases play an important role in analytical and industrial chemistry as they are used to resist the corrosion of metals. Photolysis is not considered a degradation pathway for azo dyes. In order to extend the life of products dyed with azo dyes, it is necessary to ensure stability against microbial attack, and tests have shown that azo dyes degrade significantly in short-term tests under aerobic conditions. However, under anaerobic conditions, color change can be observed as a result of biodegradation .A general method for the synthesis of new Azo compound has been employed. Diazotization reaction between 2-amino pyrimidine and 2-amino-4-nitro phenol was used to produce Azo compound F1 [2-amino-4-nitro-6-(pyrimidin-2-yldiazenyl)phenol] then prepare two Azo-Shiff base derivatives by Aldol-condensation reaction of (F1) with p-N,N-dimethyl amino Benzaldehyde and Isatin to give (F2,F3).The research included biological screening as anti-bacterial for (F,F2,F3) and as anti-cancer for (F3) by using cell line type Hep G2. FT-IR,1H-NMR, 13C-NMR and two-dimensional(2D)HSQC spectroscopy was used to characterize these compounds.