Proliposomal Formulation: A safer and effective approach for drug delivery with special mention to NSAIDS

Abstract

Proliposomes formulations have shown their importance and significance for the efficient delivery of medicament, especially in those cases where liposomal preparations are required with more stability. These are freely flowable powder preparation where a drug entangled with lipid and cholesterol is deposited over water-soluble carrier material which get converted into liposomes after dispersion in suitable media in-vitro or in-vivo. In past decades, several studies have been published regarding the safer and more effective use of Proliposomes for the administration of drugs via different routes such as oral, transdermal, vaginal etc. It has also been noted that they show their more utility for oral administration of drugs like NSAIDs where gastric absorption, bioavailability, and GI toxicity is a major concerns. The current review includes the various methods used for the pro-liposome preparation, methods to be used for its evaluation along with the application of proliposomes preparation for different purposes and routes of administration. It also includes a summary of work related to the pro-liposomes formulation development of NSAIDs.