The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits

Abstract

Tambelo reportedly has a positive impact on health. Our study investigates the possible effect of tambelo extract as an anti-inflammatory in mice induced by lipopolysaccharide(LPS)Tambelo phytochemistry from liquid chromatography analysis – high-resolution mass spectrometry (LCMS) coupled with NF-κB protein, docking was carried out to pursue anti-inflammatory properties. Thirty Balb/C mice were randomized into six groups: untreated, LPS, dexamethasone + LPS, and tambelo extract with doses of 100, 150, and 200 mg/kg BW + LPS, respectively. The results of this study indicate that there are four compounds which has a high affinity for the target protein. High CD4+CD25+ expression after treatment with fermented products tambelo (BE) significantly attenuated LPS-induced mice (p<0.05). Our findings show that fermentation tambelo protects against induced LPS by maintaining Tregs. Tambelo may have the potential as a food choice due to its anti-inflammatory properties.