Response of New Para Hydroxy Benzoic Acid Derivative and Coriandrum sativum leaves extract against periodontitis causing bacteria

Abstract

Bacteria ability to predominate the periodontitis (PI), antimicrobial potential of Coriandrum sativum and para hydroxy benzoic acid intended present study to compare the antimicrobial potential of new para hydroxy benzoic acid derivative and hydroalcoholic extract of Coriandrum sativum leaves (HECSL) against periodontitis causing bacteria (PCB). Present study involved synthesis of a new para hydroxy benzoic acid derivative and preparation of HECSL. Synthesized compound was characterized using ATR-IR, 1H-NMR and Mass spectrometric data. Both new para hydroxy benzoic acid derivative (PHBAD) and HECSL were further tested for their antibacterial potential against PCB such as Escherichia coli and Staphylococcus aureus. Both PHBAD and HECSL exhibited high antibacterial potential against PCB, however PHBAD exhibited much higher antibacterial potential. Present study concludes that PHBAD possess high antibacterial potential against PCB and recommends that PHBAD should be further evaluated for its preclinical significance.