Antihyperglycemic activity of Ficus carica leaves extracts on Streptozotocin induced diabetic rats

Author:

Roy Tathagata1,Paul Susanta1,Roy Chowdhury Victor1,Das Arijit2,Chandra Srikanta3,Das Avik4,Jana Abhishek5,Bhattacharya Muniraj5,Ghosh Nibir5

Affiliation:

1. Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata -700109.

2. Assistant Professor, Bharat Technology, Uluberia, Howrah.

3. Assistant Professor, Jakir Hossain Institute of Pharmacy, Murshidabad.

4. Assistant Professor, Gupta College of Technological Sciences, Asansol.

5. Department of Pharmaceutical Technology, JIS University, Kolkata 700109.

Abstract

Antihyperglycemic activity of leave extracts of Ficus carica was evaluated on STZ induced diabetic rats. Diabetes was induced in albino Wistar rats of either sex by intraperitoneal (60mg/kg b.w.) of STZ, freshly dissolved in citrate buffer (0.01 M, pH 4.5). Ficus carica leave extract in different solution (viz. petroleum ether, ethyloacetate, methanol and aqueous) were administered to diabetic rats for 9 days. The effect of extracts on blood glucose and body weight was studies on day 1st and 9th. The study showed that the ethyl acetate, methanolic and aqueous extract of Ficus sarmentosa leaves reduced blood glucose level and body weight significantly. This may justify the use of ficus species as ethanomedical medicine for treatment of diabetes mellitus.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference17 articles.

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3. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature. 2001;409 (6818):307-312.

4. Pickup JC, Williams G Classification and diagnosis of diabetes mellitus and impaired glucose tolerance. In: Textbook of diabetes. Blackwell Scientific Publications, London, UK. 1991; pp 37-44.

5. Kunwar, R., Adhikari, N., and Devkota, M. Indigenous use of mistletoes in tropical and temperate region of Nepal. Banko Janakari , 2005, 15(2), 38-42.

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