Gastroretentive Drug Delivery System: An Overview-Reference-Cited by-同舟云学术

Gastroretentive Drug Delivery System: An Overview

Published:2022-03-24 Issue: Volume: Page:1343-1347
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Sanghavi Rupal S.¹,Agrawal Omprakash²,Rageeb Md.³,Usman Md.³

Affiliation:

1. Ph.D Scholar, Department of Pharmacy, Madhyanchal Professional University, Bhopal (M.P).

2. Professor, Department of Pharmacy, Madhyanchal Professional University, Bhopal (M.P).

3. Associate Professor, Department of Pharmacognosy, Smt. S.S Patil College of Pharmacy, Chopda (M.S.)

Abstract

Oral route is considered as the most convenient, accepted and safest way for drug delivery, achieving better therapeutic effectiveness by delivery of drug at specific site in controlled manner is getting more attention now a days and GRDDS is one of the novel approaches which prolongs gastric residence time and releases a drug at specific targeted site of stomach for local or systemic effects. This approach is useful for drugs having narrow absorption window in upper part of GI tract. In this review we have discussed various aspects of GRDDS like merits, demerits, physiology of stomach, and potential drug candidate for GRDDS, factors affecting gastric retention, polymers and other materials used in GRDDS, Various approaches for gastric retention and evaluation of GRDDS concisely.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference78 articles.

1. Jimenez M, Zia H, Rhodes C. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. International Journal of Pharmaceutics. 1994; 105: 65-70.

2. Sakr F. A programmable drug delivery system for oral administration. International Journal of Pharmaceutics. 1999; 184: 131-139

3. Sangalli M, Maroni A, Zema L, Busetti C, Giordano F, Gazzaniga A. In vitro and in vivo evaluation of an oral system for time and/or sitespecific drug delivery. Journal of Controlled Release. 2000; 73: 103-110.

4. Singh B, Kim K. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 2000; 63: 235-259.

5. Zakeri P, Nemati M, Ghanbarzadeh S, Hamishehkar H, Valizadeh H. Fasted state bioavailability of two delayed release formulations of divalproex sodium in healthy Iranian volunteers. Drug Research. 2011; 61: 439-43.