Involvement of interferon-gamma and tumor necrosis factor-alpha in the formation of unstable atherosclerotic plaque-Reference-Cited by-同舟云学术

Involvement of interferon-gamma and tumor necrosis factor-alpha in the formation of unstable atherosclerotic plaque

Published:2024-09-11 Issue:1 Volume:24 Page:59-66
ISSN:2687-1378
Container-title:Medical academic journal
language:
Short-container-title:Medical academic journal

Author:

Snegova Vlada A.¹^ORCID,Pigarevsky Peter V.¹^ORCID,Maltseva Svetlana V.¹^ORCID,Yakovleva Olga G.¹^ORCID

Affiliation:

1. Institute of Experimental Medicine

Abstract

Research on the role of various interleukins in atherosclerosis has shown that pro-inflammatory cytokines contribute to disease progression and destabilization of atherosclerotic plaques. The review presents the latest data from the scientific literature and the study’s own findings on the effects of pro-inflammatory cytokines INF-γ and TNF-α on the formation of unstable atherosclerotic lesions. It has been shown that the deterioration of the unstable plaque cap strength and its destruction can be associated with an increase in concentration, activation and action of powerful pro-inflammatory cytokines INF-γ and TNF-α in the vascular wall.

Publisher

ECO-Vector LLC

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