Abstract
BACKGROUND: Studies on the morphological and hemodynamic changes in the structure of the portal vein of the liver and the splenic vein in various pathologies, one of which is portal hypertension, remains relevant.
AIM: To perform a histological study on the structure and thickness of the membranes of the portal vein of the liver and splenic vein in people of different age groups with normal conditions and with portal hypertension.
MATERIALS AND METHODS: Sectional material for the study of the portal vein of the liver and splenic vein was obtained from 89 people aged 730 years old who died from injuries incompatible with life. A total of 57 cases had a history of portal hypertension during life, and the remaining 32 cases were considered as controls. The cellular and tissue components of the vein walls were studied in paraffin sections stained with hematoxylineosin and Van Giesons stain (picric acid and fuchsin) using Weigerts hematoxylin.
RESULTS: The thicknesses of the inner and middle membranes of venous vessels significantly increased in all age groups with portal hypertension relative to those in the control. The pathological features of changes in the thickness and microstructure of the components of the portal vein wall of the liver and splenic vein in topographically different parts of the veins were observed.
CONCLUSION: The histological and morphometric examination of the wall of the portal vein of the liver and the splenic vein in normal cases and cases of portal hypertension syndrome in different age periods revealed not only the structural features of the portal vein of the liver and splenic vein, but also the features of age-related pathomorphological changes in the individual parts of the veins and in each of the membranes. Such features are of considerable interest for clinical medicine.