Microfiltration Device For Circulating Tumor Cells Isolation (MEMS)-(CTCS)

Abstract

Introduction: This document proposes the design and simulation of a microfilter device for the capture of circulating tumor cells, motivated by support for prevention and treatment methods against cancer, the objective of the proposal is the designed a device for separating cancer cells from blood fluid, with high efficiency. Methods: Initially, it was characterized the behavior of cells in blood fluid red blood cells (RBC), white blood cells (WBC) cancer cells (CTC), defining the dynamic model, boundary conditions, types of multiphase fluid, and flow rate, the mechanical properties of the cell membrane and the viscosity of each type are defined, for cancer cells according to the literature, the cell was squeezed and the critical pressure was analyzed. The design of the filtration device by a variation of the flow, geometry, critical streamline analysis, and vortex generation, the best hydrodynamic condition generated is selected due to favorable behavior of cell classification, the first stage circulating cancer cells, in the second output white cells and RBCs are sorting. Conclusions: Finally, the final geometry was evaluated and the efficiency of the filter device was determined, which performs the filtering process, in the first stage the cancer cells are captured with 99.99% efficiency, in the final output the white cells and red cells are captured 99.99% since the red cells are completely filtered and the white cells separated using the viscous properties and surface tension the filter generates 100% purity by sorting CTCs with no RBC or WBC contamination.