Improvement of Functional Outcomes in Patients with Stroke who Received Alteplase for Over 15 Years: Japan Stroke Data Bank

Author:

Ishigami Akiko1,Toyoda Kazunori2,Nakai Michikazu3,Yoshimura Sohei2,Wada Shinichi3,Sasahara Yusuke3,Sonoda Kazutaka4,Miwa Kaori2,Koge Junpei2,Shiozawa Masayuki2,Iwanaga Yoshitaka3,Miyamoto Yoshihiro3,Nakahara Jin1,Suzuki Norihiro1,Kobayashi Shotai5,Minematsu Kazuo6,Koga Masatoshi2

Affiliation:

1. Department of Neurology, Keio University School of Medicine

2. Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center

3. Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center

4. Department of Neurology, Saiseikai Fukuoka General Hospital

5. Shimane University School of Medicine

6. Medical Corporation ISEIKAI

Publisher

Japan Atherosclerosis Society

Subject

Biochemistry (medical),Cardiology and Cardiovascular Medicine,Internal Medicine

Reference26 articles.

1. 1) Yamaguchi T, Mori E, Minematsu K, Nakagawara J, Hashi K, Saito I, Shinohara Y, Japan Alteplase Clinical Trial (J-ACT) Group: Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT). Stroke, 2006; 37: 1810-1815

2. 2) Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med, 2008; 359: 1317-1329

3. 3) Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Tilley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, del Zoppo GJ, Baigent C, Sandercock P, Hacke W: Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet, 2014; 384: 1929-1935

4. 4) Guideline Committee of the Japan Stroke Society for IV Rt. PA (alteplase) in acute ischemic stroke. Guidelines for IV application of rt-PA (alteplase), October 2005 [in Japanese]. Jpn J Stroke, 2005; 27: 327-354

5. 5) Minematsu K, Toyoda K, Hirano T, Kimura K, Kondo R, Mori E, Nakagawara J, Sakai N, Shiokawa Y, Tanahashi N, Yasaka M, Katayama Y, Miyamoto S, Ogawa A, Sasaki M, Suga S, Yamaguchi T: Guidelines for the intravenous application of recombinant tissue-type plasminogen activator (alteplase), the second edition, October 2012: a guideline from the Japan Stroke Society. J Stroke Cerebrovasc Dis, 2013; 22: 571-600

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