FUNCTIONAL CHARACTERISTICS OF THE RAGE MOLECULE IN INTERCELLULAR INTERACTIONS IN NORMAL AND LUNG PATHOLOGY-Reference-Cited by-同舟云学术

FUNCTIONAL CHARACTERISTICS OF THE RAGE MOLECULE IN INTERCELLULAR INTERACTIONS IN NORMAL AND LUNG PATHOLOGY

Published:2024-08-02 Issue:4 Volume:22 Page:3-11
ISSN:2499-9490
Container-title:Molekulyarnaya Meditsina (Molecular medicine)
language:
Short-container-title:Mol Med Rus

Author:

Zubareva T.S.¹,Lykova K.O.²,Panfilova A.S.³,Yablonsky P.R.¹,Kvetnaia T.V.⁴,Paltsev M.A.⁵

Affiliation:

1. St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, Ligovskiy Prospekt, 2–4, St. Petersburg, 191036, Russian Federation;

2. Federal State Autonomous Educational Institution of Higher Education “Peter the Great St. Petersburg Polytechnic University”, st. Politekhnicheskaya, 29, St. Petersburg, 195251, Russian Federation;

3. St. Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, Ligovskiy Prospekt, 2–4, St. Petersburg, 191036, Russian Federation; -ANO Scientific Research Center “St. Petersburg Institute of Bioregulation and Gerontology”, Dynamo Ave., 3, St. Petersburg, 197110, Russian Federation

4. ANO Scientific Research Center “St. Petersburg Institute of Bioregulation and Gerontology”, Dynamo Ave., 3, St. Petersburg, 197110, Russian Federation;

5. Federal State Budgetary Educational Institution of Higher Education “Moscow State University named after M.V. Lomonosov”, Leninskie Gory, 1, Moscow, 119991, Russian Federation; Federal State Autonomous Educational Institution of Higher Education “Russian Peoples' Friendship University named after Patrice Lumumba”, st. Miklouho-Maklaya, 6, Moscow, 117198, Russian Federation

Abstract

Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unknown in most cases. Purpose of the study. Analysis of information about the role of RAGE and its signaling cascades in the pathogenesis of inflammatory, fibrotic and oncological lung diseases for a deeper understanding of signal modulation of this receptor. Material and methods. The review highlights the results of clinical and experimental studies obtained using methods for determining the quantitative expression of the receptor for advanced glycation end products (RAGE) and its ligands. When preparing materials, sources were used from international and domestic databases Scopus, Web of Science, Pub Medline, eLibrary, mainly over the past 15 years. Results. By binding the wide range of ligands, RAGE is directly involved in the inflammatory response to injury, fibrosis processes in the lungs and the occurrence of malignant neoplasms, thereby playing an important role in the development of many lung diseases. Conclusions. To obtain an informative picture of the pathogenesis of lung diseases, it is necessary to conduct a comprehensive assessment of the expression levels of both the RAGE signaling molecule itself and its isoforms and ligands.

Publisher

Russian Vrach, Publishing House Ltd.

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