Genome editing–induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion
Author:
Funder
National Institutes of Health
Stanford Maternal and Child Health Research Institute
Alex’s Lemonade Stand Foundation
Publisher
American Society for Clinical Investigation
Subject
General Medicine
Link
https://www.jci.org/articles/view/171030/files/pdf
Reference7 articles.
1. The MLL recombinome of acute leukemias in 2017
2. Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations
3. A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
4. High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells
5. Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse
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