A mathematical modeling of the mitochondrial proton leak via quantum tunneling

Author:

Abdallat Mahmoud1,Qaswal Abdallah Barjas2,Eftaiha Majed3,Qamar Abdel Rahman4,Alnajjar Qusai5,Sallam Rawand5,Kollab Lara5,Masa'deh Mohammad5,Amayreh Anas6,Mihyar Hiba7,Aboushakra Hesham8,Alkelani Bayan8,Owaimer Rawan8,Abd-Alhadi Mohannad9,Ireiqat Salwa10,Turk Fahed11,Daoud Ahmad12,Darawsheh Bashar13,Hiasat Ahmad14,Alhalaki Majd15,Abdallat Shahem16,Hamad Salsabiela Bani17,Murshidi Rand17

Affiliation:

1. Department of Neurosurgery, Jordan University Hospital, School of Medicine, University of Jordan, Amman 11942, Jordan

2. Department of Psychiatry, Jordan University Hospital, Amman 11942, Jordan (A.B.Q)

3. Department of Neurosurgery, Jordan University Hospital, Amman 11942, Jordan

4. School of Medicine, The Hashemite University, Zarqa 13133, Jordan. (A.R.Q)

5. Department of Internal Medicine, Jordan University Hospital, Amman 11942, Jordan

6. Department of General Surgery, Jordan University Hospital, Amman 11942, Jordan

7. Department of Emergency, Jordan University Hospital, Amman 11942, Jordan

8. Department of Family Medicine, Jordan University Hospital, Amman 11942, Jordan

9. School of Medicine, Near East University, Nicosia, Cyprus

10. School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan

11. Tver State Medical University, Ulitsa Sovetskaya, 4, Tver, Tver Oblast, Russia, 170100

12. Cardiovascular Research Department, King's College London, London WC2R 2LS, United Kingdom

13. School of Medicine, Yarmouk University, Irbid 21163, Jordan

14. Hamad Medical Corporation, PO Box 3050 Doha, Qatar

15. School of Medicine, University of Jordan, Amman 11942, Jordan

16. School of Medicine, Xavier University, Santa Helenastraat 23, Oranjestad, Aruba

17. Department of Dermatology, Jordan University Hospital, Amman 11942, Jordan

Abstract

<abstract> <p>The mitochondrion is a vital intracellular organelle that is responsible for ATP production. It utilizes both the concentration gradient and the electrical potential of the inner mitochondrial membrane to drive the flow of protons from the intermembrane space to the matrix to generate ATP via ATP-synthase. However, the proton leak flow, which is mediated via the inner mitochondrial membrane and uncoupling proteins, can reduce the efficiency of ATP production. Protons can exhibit a quantum behavior within biological systems. However, the investigation of the quantum behavior of protons within the mitochondria is lacking particularly in the contribution to the proton leak. In the present study, we proposed a mathematical model of protons tunneling through the inner mitochondrial membrane and the mitochondrial carrier superfamily MCF including uncoupling proteins UCPs and the adenine nucleotide translocases ANTs. According to the model and its assumptions, the quantum tunneling of protons may contribute significantly to the proton leak if it is compared with the classical flow of protons. The quantum tunneling proton leak may depolarize the membrane potential, hence it may contribute to the physiological regulation of ATP synthesis and reactive oxygen species ROS production. In addition to that, the mathematical model of proton tunneling suggested that the proton-tunneling leak may depolarize the membrane potential to values beyond the physiological needs which in turn can harm the mitochondria and the cells. Moreover, we argued that the quantum proton leak might be more energetically favorable if it is compared with the classical proton leak. This may give the advantage for quantum tunneling of protons to occur since less energy is required to contribute significantly to the proton leak compared with the classical proton flow.</p> </abstract>

Publisher

American Institute of Mathematical Sciences (AIMS)

Reference48 articles.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3