Reversal of Cisplatin and Multidrug Resistance by Ribozyme-Mediated Glutathione Suppression

Author:

Nagata Junko,Kijima Hiroshi,Hatanaka Hiroyuki,Asai Satomi,Miyachi Hayato,Takagi Atsushi,Miwa Takeshi,Mine Tetsuya,Yamazaki Hitoshi,Nakamura Masato,Kondo Takahito,Scanlon Kevin J.,Ueyama Yoshito

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference59 articles.

1. Regulation of γ-glutamylcysteine synthetase by nonallosteric feedback inhibition by glutathione;Richman;J. Biol. Chem.,1975

2. Hammerhead ribozymes against γ-glutamylcysteine synthetase mRNA down-regulate intracellular glutathione concentration of mouse islet cells;Kijima;Biochem. Biophys. Res. Commun.,1998

3. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis;Godwin;Proc. Natl. Acad. Sci. USA,1992

4. Significance of glutathione S-transferase π as a tumor marker in patients with oral cancer;Hirata;Cancer,1992

5. Increase in γ-glutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing eleavated glutathine levels;Bailey;Cancer Res.,1992

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