Thirdhand smoke exposure and its toxicological impacts: A review on target organ based studies
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Published:2023-02-22
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Volume:
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ISSN:1300-4182
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Container-title:Fabad Journal of Pharmaceutical Sciences
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language:en
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Short-container-title:Fabad J Pharm Sci
Author:
KOLCİ Kübra1ORCID, GARİPKUŞ Sena Nur1ORCID, REİS Rengin2ORCID
Affiliation:
1. ACIBADEM ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ 2. ACIBADEM MEHMET ALİ AYDINLAR ÜNİVERSİTESİ
Abstract
Third-hand smoke (THS) is a newly described environmental health hazard that might be defined as a residual cigarette smoke that occurs due to the accumulation of toxins of second-hand smoke (SHS) in the smoking environment. In addition, chemicodynamic of THS may alter due to the interaction with other gases and chemicals present in the environment. THS may cause serious health outcomes in the lungs, liver, skin, heart, and nervous system as well. Hence, it is thought to represent a major health hazard for people, particularly for children, whom exposed to THS where they interact more frequently with these surfaces exposed to THS via hand to mouth transfer. In the present study, it was aimed to summarize the proposed toxicity mechanisms based on in vitro and in vivo studies based on target organ toxicity. In this study, it is aimed to review toxicity mechanisms of THS based on in vitro and in vivo studies on target organ toxicity. Recent studies reported that THS might induce unwanted effects in the respiratory, cardiovascular, nervous, hematopoietic, and skeletal systems and skin. Literature data indicated that THS-mediated oxidative damage and increase in inflammatory response may play an important role in the pathogenesis of cardiovascular and neurobehavioral diseases, especially the target organ lung, and in the future, THS might be defined as a preventable environmental risk factor. Therefore, further studies on THS are needed to define its toxicity mechanism as well as increase the social awareness and legal regulations.
Publisher
FABAD Farmasotik Bilimler Ankara Dernegi
Subject
Pharmaceutical Science
Reference51 articles.
1. Acuff, L., Fristoe, K., Hamblen, J., Smith, M., & Chen, J. (2016). Third-Hand Smoke: Old Smoke, New Concerns. Journal of Community Health, 41(3), 680–687. 2. Akhavan Rezayat, A., Dadgar Moghadam, M., Ghasemi Nour, M., Shirazinia, M., Ghodsi, H., Rouhbakhsh Zahmatkesh, M. R., Tavakolizadeh Noghabi, M., Hoseini, B., & Akhavan Rezayat, K. (2018). Association between smoking and non-alcoholic fatty liver disease: A systematic review and meta-analysis. SAGE Open Medicine, 6, 2050312117745223. 3. Bahl, V., Weng, N. J., Schick, S. F., Sleiman, M., Whitehead, J., Ibarra, A., & Talbot, P. (2016). Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. Toxicological Sciences: An Official Journal of the Society of Toxicology, 150(1), 234–246. 4. Bogdanovica, I., Godfrey, F., McNeill, A., Britton, J. (2011). Smoking prevalence in the European Union: a comparison of national and transnational prevalence survey methods and results. Tobacco Control, 20(1). 5. Bundy, Ł. T., Haardörfer, R., Kegler, M. C., Owolabi, S., Berg, C. J., Escoffery, C., Thompson, T., Mullen, P. D., Williams, R., Hovell, M., Kahl, T., Harvey, D., Price, A., House, D., Booker, B. W., & Kreuter, M. W. (2020). Disseminating a Smoke-free Homes Program to Low Socioeconomic Status Households in the United States Through 2-1-1: Results of a National Impact Evaluation. Nicotine & tobacco research: Official Journal of The Society for Research on Nicotine and Tobacco, 22(4), 498–505.
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